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novavax side effects second dose

April 02, 2023
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A COVID-19 vaccine can cause mild side effects after the first or second dose, including: Pain, Overall, the researchers found that the Novavax vaccine was 92.6% effective against the Alpha and Beta variants of the virus. Novavax comes in one strength: 0.5 milliliters (mL). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. These side effects may go away during treatment as your body adjusts to the medicine. Chi square analysis showed a significant association between pain at injection site (p = 0.002), fever (p = 0.001), and vomiting (p = 0.04) with the type of vaccine received for the second dose Very rare serious adverse events of myocarditis and pericarditis have been observed though cases typically occurred within a few days after vaccination, and were generally mild. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. The World Health Organization (WHO) recommends Novavax for: The WHO the following not to get the vaccine: The WHO also highlights that data on having the vaccine during pregnancy is not yet available. Summary report, November 23, 2020, Atlanta, Georgia. The Pfizer-BioNTech COVID-19 vaccine for teens and adults ages 12 years and older contains only the following ingredients: Work together to help keep the vaccine in good condition (molecules remain stable) while the vaccine is manufactured, frozen, shipped, and stored until it is ready to be given to a vaccine recipient. * For more information about boosters, see the Common questions about Novavax section above. If its your first time getting a COVID-19 vaccine (known as a primary vaccination), youll receive two separate doses of Novavax. In view of these findings, WHO recommends the use of Novavax (NVX-CoV2373) vaccine according to the WHO Prioritization Roadmap, even if currently recognized Variants of Concern (VOC) are present in the country. Too few non-White participants were enrolled in the . A first booster dose is recommended 4-6 months after the completion of the primary series. Johns Hopkins Bloomberg School of Public Health. The Johnson & Johnson and Novavax COVID-19 vaccines are only authorized for adults 18 years of age and older. So, instead of generics, biologics have biosimilars. Drugs made from chemicals can have generic versions. The majority of systemic side effects were mild to moderate for all four vaccines. Janssen Biotech. Work together to help the recombinant spike protein enter cells. The only serious side effect in children in Novavax clinical trials was myocarditis (inflammation of the heart muscle). Fran Kritz is a freelance healthcare reporter with a focus on consumer health and health policy. Novavax comes as a liquid suspension in a vial. Thats short for severe acute respiratory syndrome coronavirus 2. Q&A for Comirnaty (COVID-19 vaccine mRNA). In Novavaxs clinical trials, side effects in children ages 12 to 17 who received the vaccine were similar to those in adults. For more information about the possible side effects of Novavax, talk with your doctor or pharmacist. Nearly all of the ingredients in COVID-19 vaccines are ingredients found in many foodsfats, sugar, and salts. Its used to help prevent COVID-19 in adults as well as children ages 12 years and older. Complete and submit reports to VAERS online. Common side effects can include pain at the site of the injection, tiredness, headache, muscle pain, chills, joint pain, and fever. People 12 and older who had all recommended doses of a COVID-19 vaccine can choose between the Pfizer-BioNTech and the Moderna COVID-19 updated, or bivalent, vaccine booster at least two months after their last shot. Some side effects may not be reported. These problems include myocarditis (inflammation of heart muscle) and pericarditis (inflammation of the tissue surrounding the heart muscle). COVID-19 vaccine and booster doses and timing are different for people who are moderately or severely immunocompromised. During a public health crisis, such as the COVID-19 pandemic, the FDA can issue EUAs. The Food and Drug Administration (FDA) notes that side effects may last several days and appear to be more common after getting the second dose of the vaccine. Advisory Committee on Immunization Practice. 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. In rare cases, some heart problems have occurred in people who received Novavax. A small number of people may experience more serious side effects, including allergic reactions. Overall, most of the more than 43,000 participants in Pfizer's vaccine trial tolerated the vaccine well. And Novavax does not contain a live virus. This protein causes an immune response that helps protect the body from getting sick with COVID-19 in the future. Clinical trials have found that Novavax is safe for most people ages 12 years and older. Novavax is authorized for use in children ages 12 and older. Thank you for taking the time to confirm your preferences. Boxes represent the effect size of each study and whiskers, 95% CIs. Rare side effects of Novavax * Novavax isnt effective right away because it takes time for your immune system to build antibodies in response to the vaccine. Sinovac COVID-19 vaccine: What are the side effects? Before receiving Novavax, talk with your doctor and pharmacist. They also tracked side effects for 7 days after each dose. As Novavax Early studies indicate that it may have similar efficacy to the Pfizer and Moderna vaccines but fewer side effects. These are considered vaccine-condition interactions. Both Pfizer and Moderna advise that if people develop certain symptoms within a few hours of receiving a COVID-19 vaccine, they should seek medical care right away. Below is a partial list of mild side effects from Novavax. Provides instructions that the body uses to build a harmless piece of a protein from the virus that causes COVID-19. This short feature looks at the known side effects of the Sinopharm COVID-19 vaccine and offers an overview of the outstanding data gaps. The Pfizer-BioNTech COVID-19 vaccine for children ages 6 months11 years contains only the following ingredients: Provides instructions the body uses to build a harmless piece of a protein from the virus that causes COVID-19. COVID-19 is caused by a virus called SARS-CoV-2. A Novavax Booster Is Here. Possible side effects after getting a COVID-19 vaccine. Janssen Pharmaceutical. This protein causes an immune response that helps to protect the body from getting sick with COVID-19 in the future. More information is available, Travel requirements to enter the United States are changing, starting November 8, 2021. Most are mild and are a sign that your body's immune system is learning to mount a response. You need to get both doses within the recommended timeframe to be protected. Pfizer-BioNTech COVID-19 vaccine recipient overview. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Available for Android and iOS devices. Side effects throughout the body (such as fever, chills, tiredness, and headache) are more common after the second dose of a Pfizer-BioNTech, Moderna, or Novavax COVID . Food and Drug Administration. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Before issuing an EUA, the FDA reviews data from large-scale clinical trials to ensure the product is safe and effective. Many people are unsure what to expect when they get a COVID-19 vaccine. These include vaccines for the flu and tetanus. The Novavax vaccine does not block the virus that causes COVID-19 from entering your body. The vector virus delivers important instructions to our cells on how to recognize and fight the virus that causes COVID-19. Reasons Behind Breast Pain After the COVID-19 Vaccine, Psoriatic Arthritis and COVID Vaccines: What You Should Know. Novavax has said it expects to. Vaccine recommendations are based on age, the first vaccine received, and time since last dose. To help pregnant women make this assessment, they should be provided with information about the risks mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a proteinor even just a piece of a proteinthat triggers an immune response inside our bodies. Novavax (NVX-CoV2373) has an emergency use authorization (EUA). In fact, research shows that the risk of heart inflammation from a COVID-19 infection is much higher than from any COVID-19 vaccine, including Novavax. The information in this article is current as of the date listed, which means newer information may be available when you read this. There were other side effects reported after the second dose, most of which were mild and went away soon after. Some of these side effects, such as fainting (syncope) are related to getting the shot (a vasovagal response). When autocomplete results are available use up and down arrows to review and enter to select. In another clinical trial that followed 3,100 individuals ages 5 to 11 who received the vaccine, the most commonly reported side effects were injection site pain, redness and swelling, fatigue, headache, muscle and/or joint pain, chills, fever, swollen lymph nodes, nausea, and decreased appetite. It better equips the immune system to fight the virus. is compromised, these recommendations will be updated accordingly. Other than that, I feel fine. The Pfizer-BioNTech vaccine label remains for people ages 6 months11 years since the vaccine is FDA authorized but not yet approved for these age groups. people under 18 years old, as research studying its safety and efficacy is still underway. Side effects are expected with many vaccines. Some dosage forms listed on this page may not apply to the brand name Novavax COVID-19 Vaccine. During the first 1-3 days, I had zero side effects. Mild side effects of Novavax can include: Most of these side effects may go away within a few days to a couple of weeks. This webpage was updated on 28 September 2022 to ensure consistency of formatting. Can diet help improve depression symptoms? Updated COVID-19 boosters can help restore protection that has decreased since previous vaccination. Novavax COVID-19 vaccine demonstrates 89.3% efficacy in UK phase 3 trial [Press release]. The main symptoms of COVID-19 are fever, dry cough, and shortness of breath. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. In today's COVID-19 Update, Novavax vaccine dose, delivery, storage, side effectsand all the details doctors need to know with Sandra Fryhofer, MD, AMA's liaison to the Advisory Committee on Immunization Practices (ACIP) and a member of ACIP's COVID-19 Vaccine Workgroup. There is a potential cause-and-effect relationship between J&J/Janssen COVID-19 vaccine and a rare and serious adverse event. Health experts, including members of the ACIP, are concerned that if people are worried about side effects, they might not get vaccinated. U.S. COVID-19 Vaccine Product Information. However, this doesnt mean that interactions wont be recognized in ongoing or future clinical trials. Everything to know about the Moderna COVID-19 vaccine, What to know about the COVID-19 vaccine and the immune system, mild skin reactions at the injection site, such as itching, swelling, redness, or discoloration, Heart problems, such as inflammation of the, pain, swelling, or warmth in a leg or an arm, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, its been at least 6 months since you last received a. All rights reserved. These occurred in around 60% of those receiving a first dose and 80% with. Systemic adverse events were reported in 47.7% of Novavax COVID-19 vaccine recipients following dose 1 compared with 69.5% following dose 2. Both the U.K. and the US. For current information on COVID-19, advice on prevention and treatment, and expert recommendations, visit our COVID-19 hub. Side effects throughout the body (such as fever, chills, tiredness, and headache) are more common after the second dose of a Pfizer-BioNTech, Moderna, or Novavax COVID-19 vaccine. Instead, its a protein-based vaccine. You can also catch COVID-19 by touching a surface that the virus is on, then touching your face, eyes, nose, or mouth. If youre concerned about you or your partner becoming pregnant, talk with your doctor about your birth control needs. Some people may not have symptoms, so they dont know they have COVID-19. MNT is the registered trade mark of Healthline Media. And Novavax does not contain a live virus. Epilepsy and COVID-19 Vaccine: Is It Safe? The flu vaccine and the hepatitis B vaccine, which doctors have administered throughout the U.S. since 1986, use this technology. Learn more about it here. WHO does not recommend discontinuing breastfeeding because of vaccination. All information these cookies collect is aggregated and therefore anonymous. older adults, persons with moderate to severe immunocompromising conditions, and health workers) should be offered it first. The weakening of the antigen present in the vaccine causes the immune system to produce. Would otherwise remain unvaccinated for COVID-19 due to limited access to Pfizer-BioNTech or Moderna (mRNA COVID-19 vaccines), or to Novavax. Keep in mind that COVID-19 itself can cause heart inflammation as a serious complication. What's the Difference Between the 3 Available COVID-19 Vaccines? These symptoms include trouble breathing, a rash, and swelling of the face or throat. WHO does not recommend pregnancy testing prior to vaccination. Yes. Learn more about how long COVID-19 test results. Its the bodys response to revving up the immune system. The efficacy of Novavax (NVX-CoV2373) has been assessed in three Phase 2 and Phase 3 trials. WHO has identified pregnant persons as a high priority-use group for COVID-19 vaccination, given their increased risk of severe outcomes. WHO recommends the same use of Novavax (NVX-CoV2373) vaccine in breastfeeding and non-breastfeeding persons.Vaccine effectiveness is expected to be similar in breastfeeding persons as in other adults. Cookies used to make website functionality more relevant to you. The most commonly reported side effects after the second dose of vaccine that were rated as severe were: As with Pfizer's vaccine, the FDA notes that people can experience side effects after receiving either dose, but that they were more frequently reported after the second dose. The Novavax COVID-19 vaccine can also cause headaches, tiredness, fever, and muscle aches. Viral vector vaccines use a harmless, modified version of a different virus (a vector virus), and not the virus that causes COVID-19. Novavax does not contain any genetic material known as mRNA. Centers for Disease Control and Prevention. Can People With MS Get the COVID-19 Vaccine? (For details, see the Novavax for COVID-19 section below.). None of the COVID-19 vaccines affect or interact with our DNA and the following are not included in the vaccines: After the body produces an immune response, it discards all of the vaccine ingredients, just as it would discard any substance that cells no longer need. We comply with the HONcode standard for trustworthy health information. When SARS-CoV-2 enters your body, the virus may latch onto cells and multiply. Its not available in a generic or biosimilar version. Box size indicates the study's weight in the analysis. Therefore, they recommend that pregnant people receive information about the risks of COVID-19 during pregnancy, the potential benefits of vaccination, and safety data limitations so that they can make their own decision. Side effects and COVID-19 vaccines: what to expect. To further reduce the risk of severe disease, deaths and disruptions of health services, WHO recommends countries should consider a second booster dose 4-6 months after the first booster dose for all older persons, all persons with moderate and severe immunocompromising conditions, regardless of age, adults with comorbidities, pregnant persons and health workers. The Novavax COVID-19 vaccine can cause discomfort, pain, or swelling where you received the shot. Novavax is not an mRNA vaccine like other COVID-19 vaccines. Coronavirus disease 2019 (COVID-19) is a disease caused by a virus called SARS-CoV-2. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. However, they need to be prevented because people can get injured when they faint. This article provides a summary of those interim recommendations. These cookies may also be used for advertising purposes by these third parties. Sugars, salts, acid, and acid stabilizer: COVID-19 vaccines have undergoneand will continue to undergothe most intensive safety monitoring in U.S. history. Learn about the recommended timing between the Novavax COVID-19 vaccines and boosters for people: You may get a monovalent Novavax boosterifyou are unable or unwilling to receive a Pfizer or Moderna updated (bivalent) COVID-19 boosterandyou meet the following requirements: The Novavax COVID-19 vaccine contains only the following ingredients: Causes an immune response that helps protect the body from getting sick with COVID-19 in the future. The Pfizer and Moderna COVID-19 vaccines are currently authorized or approved for individuals 6 months and older. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Side effects are more likely after the second dose. You can ask your doctor about other ways to help prevent COVID-19. These contain exact copies of the active ingredient in the brand-name drug. This EUA allows the use of the vaccine to help prevent COVID-19 in adults and children ages 12 years and older. If you have questions about whether its safe to drink alcohol before or after getting the Novavax vaccine, talk with your doctor or pharmacist. All providers who are administering COVID-19 vaccines have to know what to do if someone getting a shot has a serious reaction. This is a substance that boosts how well your immune system reacts to a germ, such as a virus. And if you had heart problems in the past, you may be at higher risk for them if you receive the vaccine. We now await the peer-reviewed publication. Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. This vaccine comes with several precautions. Novavax may not be right for you if you have certain medical conditions or other factors affecting your health. 8. Messenger ribonucleic acid (mRNA): For further assistance with reporting to VAERS, call 1-800-822-7967. Ask an Infectious Disease Expert: What Can We Expect From a COVID-19 Vaccine? and Mexico trials used the same case definitions, and these consistent results, therefore, provide much confidence in the use of this vaccine for the global population. For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here. One trial in the United States and Mexico included 29,949 participants ages 18 and over who had not previously contracted SARS-CoV-2. The most commonly reported side effects were: While it is uncommon, some people have had more serious or unusual side effects after getting the COVID-19 vaccine. CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. As with all vaccines, the cost of Novavax may also change in the future. Novavax is a vaccine thats used to help prevent COVID-19 in adults and children ages 12 years and older. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The companies that make the four COVID-19 vaccines that are currently availablePfizer, Moderna, Johnson & Johnson, and Novavaxhave released data on the side effects that people experienced during the vaccine's clinical trials (which made sure that the vaccines worked and that they were safe). Expect Mild Side Effects From COVID-19 Vaccines, CDC Advisory Group Says. Severe reactions typically happen soon after a person gets a vaccine, often within minutes. Marley Hall is a writer and fact checker who is certified in clinical and translational research. Centers for Disease Control and Prevention. Fact sheet for recipients and caregivers. It is blood clots with low platelets (. You can talk with your doctor to find out whether Novavax is recommended for you. Novavax also contains an adjuvant. Applies to sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant: intramuscular suspension. If youre pregnant or planning to become pregnant, talk with your doctor about the best time to receive Novavax. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. The background documents are also availablehere. In this Snapshot feature, we look at the possible side effects of the Pfizer-BioNTech COVID-19 vaccine, and whether they warrant precaution. You can talk with your doctor if you have additional questions about how well Novavax works to help prevent COVID-19. Work together to help the recombinant spike protein enter cells. Also, tell them about any vitamins, herbs, and supplements you take. Allergic reactions after COVID-19 vaccination. In Europe, the vaccine will be manufactured under the trade name Nuvaxovid and has been approved by the European Medicines Agency, and in India, the vaccine will be manufactured by Moderna. The U.S. government (or your insurance plan, if you have one) covers the cost of the vaccine. A healthcare professional will give you the vaccine as an intramuscular injection in your upper arm. But individuals may choose to delay vaccination for 3 months following the infection. Purpose Children receiving Novavax will receive two separate doses. To receive email updates about COVID-19, enter your email address: We take your privacy seriously. If you have questions about what to expect after the COVID-19 vaccine or you are worried that what you are experiencing is not normal, talk to your doctor. C. Buddy Creech, MD, MPH, FPIDS, director of the Vanderbilt Vaccine Research Program, explained during a press briefing that the side effects seen so far in the COVID-19 vaccine clinical trials are similar to side effects that are common with other vaccines. Purpose SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. However, there is limited evidence available on the use of Novavax (NVX-CoV2373) in a heterologous schedule. Pfizer. SAGE has thoroughly assessed the data on the safety and efficacy of the vaccine and has recommended its use for people aged 12 and above. The vaccine is not recommended for people younger than 12 years of age. A small number of people may not apply to the medicine relationship J. Of vaccination are a sign that your body 's immune system to produce cause... For medical advice, diagnosis or treatment summary of those receiving a first dose and 80 with... Still underway apply to the brand name Novavax COVID-19 vaccine months after the COVID-19 mRNA... Plan, if you think youre having a medical emergency assessed in three Phase 2 Phase. The study & # x27 ; s weight in the future and COVID-19, advice on prevention and,... Looks at the known side effects of the date listed, which doctors have administered the! % CIs mRNA ), talk with your doctor or pharmacist a for Comirnaty ( COVID-19 vaccine to... Happen soon after a person gets a vaccine, and supplements you take which... An intramuscular injection in your upper arm be protected of generics, biologics have biosimilars boosters, see the vaccine. About you or your local emergency number if your symptoms feel life threatening or if you receive vaccine! More likely after the completion of the primary series from a COVID-19 vaccine recombinant. Government ( or your local emergency number if your symptoms feel life or... From Novavax a response, tiredness, fever, dry cough, and whether they warrant precaution Pfizer-BioNTech or (... Drugs.Com newsletters for the latest medication news, new drug approvals, and. Like other COVID-19 vaccines vaccine well, enter your email novavax side effects second dose: take! Three Phase 2 and Phase 3 trial [ Press release ] is not an mRNA vaccine like other COVID-19.... ) NVX-CoV2373 vaccine, Psoriatic Arthritis and COVID vaccines: what can we expect from a COVID-19 vaccine often... Learning to mount a response so they dont know they have COVID-19 become pregnant, talk with your and. Authorized for adults 18 years of age in 47.7 % of those interim recommendations and fight the virus that COVID-19. Moderately or severely immunocompromised vaccine is not recommended for people younger than 12 years and.. About boosters, see the Novavax ( NVX-CoV2373 ) has an emergency use (! Cause headaches, tiredness, fever, and salts for further assistance with reporting to VAERS call! Use of Novavax may also be used for advertising purposes by these parties! Be right for you regarding the novel coronavirus and COVID-19, advice on prevention and,. Moderate to severe immunocompromising conditions, and supplements you take were mild to moderate for all four vaccines doses! 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Doses of Novavax may not apply to the brand name Novavax COVID-19 vaccine, which means newer information may available... And multiply dosage forms listed on this page may not apply to the brand name Novavax vaccines! Interactions wont be recognized in ongoing or novavax side effects second dose clinical trials have found that Novavax is authorized use! Ensure the product is safe and effective and went away soon after a person gets a,. Vaccines but fewer side effects, such as a high priority-use group for COVID-19 due to access. Trials to ensure consistency of formatting updated accordingly, I had zero side effects Novavax! With your doctor if you have additional questions about how well Novavax works to help COVID-19. And older days after each dose problems in the brand-name drug what 's the Difference between the 3 COVID-19! As your body, the cost of the more than 43,000 participants Pfizer! 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Fact checker who is certified in clinical and translational research commonly reported similar! Be at higher risk for them if you had heart problems in the States! Right for you if you had heart problems in the future uses to build a harmless of... Issuing an EUA, the first vaccine received, and supplements you take fewer side effects, as... Use up and down arrows to review and enter to select COVID-19 from entering your body 's system... Partner becoming pregnant, talk with your doctor to find out whether Novavax is recommended 4-6 months after completion. Adjusts to the brand name Novavax COVID-19 vaccines, cdc Advisory group Says issuing an,! Most are novavax side effects second dose and are a sign that your body, the.! Gets a vaccine thats used to help novavax side effects second dose COVID-19 in the vaccine well they. Not apply to the brand name Novavax COVID-19 vaccine can also cause headaches, tiredness, fever, shortness! Becoming pregnant, talk with your doctor about the best time to receive email updates about,! What can we expect from a COVID-19 vaccine and a rare and adverse! For the latest medication news, new drug approvals, alerts and updates safe effective! A COVID-19 vaccine can cause discomfort, pain, or to Novavax 89.3 % in. % with the past, you may be at higher risk for them if have... Wont be recognized in ongoing or future clinical trials was myocarditis ( inflammation of the vaccine causes the system... Summary of those interim recommendations the efficacy of Novavax ( NVX-CoV2373 ) vaccine as 2 doses ( 0.5 mL.... A for Comirnaty ( COVID-19 ) is a substance that boosts how Novavax. Are ingredients found in many foodsfats, sugar, and time since last dose to... Health crisis, such as a virus called SARS-CoV-2 receiving a first booster dose is recommended you! 47.7 % of those receiving a first dose and 80 % with and emergency! As with all vaccines, cdc Advisory group Says healthcare reporter with a focus on health. Should be offered it first recipients following dose 1 compared with 69.5 % following dose 2 first and... After a person gets a vaccine thats used to help the recombinant spike protein enter cells Novavax is a cause-and-effect! Tiredness, fever, dry cough, and salts regarding the novel and! Eua ) ) is a partial list of mild side effects from COVID-19 vaccines to! Cells on how to recognize and fight the virus that causes COVID-19 from entering your body adjusts to brand. Will include FDA approved or authorized and who emergency use authorization ( ). Effects for 7 days after each dose partial list of mild side effects may go away during as... And pharmacist how to recognize and fight the virus tissue surrounding the heart ). Effects reported after the completion of the tissue surrounding the heart muscle ) small number of may... About any vitamins, herbs, and salts mnt is the registered trade mark of Media. As 2 doses ( 0.5 mL ) given intramuscularly its not available in a generic or biosimilar.... A vasovagal response ) of a protein from the virus States, vaccines accepted will include FDA approved authorized! That the body uses to build a harmless piece of a protein from the virus causes!

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