?, Satan and The Lamb as Tainted Lazarus, All new chests become locked Golden chests, UNLOCK: Unlock this trinket by defeating Isaac, ?? For example if the spawned boss leaves creep, it can damage Isaac, UNLOCK: Unlock this item by defeating Delirium for the first time on any character, A familiar fly that orbits around a random enemy in the room until that enemy dies, dealing 2 contact damage to other enemies, Angry Fly will move to the next enemy after the one it is currently orbiting dies, until the room is cleared, at which point it will return to orbiting Isaac, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Custom Phase, UNLOCK: Unlock this item by transforming into Beelzebub (Achieved by picking up 3 fly related items, see Transformations page for full list), A throwable active item that places a black hole on the ground where it lands, sucking all enemies into it for 6 seconds, Enemies stuck inside the black hole take rapid damage over time, The Black Hole will also suck Isaac into it, but with a much weaker effect than to enemies, The Black Hole will destroy nearby obstacles such as rocks and pots, Adds a random chance for an enemy in the current room to become charmed or feared briefly, Adds a random chance to spawn a rainbow poop upon taking damage, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Electoon, UNLOCK: Unlock this item by breaking 5 rainbow poops, *, red, white, stripe, hat, clown, waldo, wally, Causes random enemies to 'lag' at random intervals, causing them to freeze in place for a second, The lag effect can also apply to tears, projectiles and consumables on the ground, While held, this item has a 25% chance to double up any end of room drops (similar to the Contract from Below effect), Isaac's Luck stat affects how often the lag effect occurs, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Freezenification, UNLOCK: Complete 7 Daily Challenges (30 on console), A one-time use item that spawns a random item from the current room's item pool, with a chance for it to spawn Lump of Coal or The Poop instead, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Mills, *, green, red, present, bow, xmas, christmas, When used, spawns a Sprinkler that rotates in a circle, spraying tears in all directions, Will also synergize with some other items, such as Mom's Eye, Brimstone, Dr. Fetus, Tech X or Loki's Horns, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Kieran and Stewartisme, Allows you to rapidly place bombs on the ground, Added as part of the Afterbirth+ Booster Pack #1. Confuses all enemies briefly when destroyed, White poop - Same effect as Hallowed Ground, Stone poop - Deals extra thrown damage, can hit multiple enemies. Like, almost all of the unlocks add something worthwhile or at least situational, as opposed to unlocks like isaac's tears or blood rights or marrow or the 5 billion coop babies. (D20 effect), 3 Dot - Rerolls all pickups on the entire floor, 4 Dot - Rerolls all pedestal items on the floor. More items consumed = more chance for this effect. bomb beggar, green, dead, face, bobs curse, bob curse, Spawns 7 random coins around Isaac on the floor, * boss room pool, boss room item, dtQt, dtphase, crown, nocrown, yescrown, diana, The second piece drops after beating the Boss Rush as long as you are holding the first Broken Shovel piece (see previous 2 items for full details), After The Forgotten is unlocked, using it on the mound of dirt again just spawns a random type of chest, Each time you get hit, you drop a coin or two, REPENTANCE - No longer guaranteed to drop coins as The Keeper, UNLOCK: Unlock this item by beating Challenge #15 (Slow Roll), * , the lost item pool, cent, gold, water, wet, blue, While held, Isaac has a significantly higher chance to find drops when breaking poops, Lowers your spacebar item charge rate by 1, Cannot lower the charge of your spacebar item below 1 room, For example, you will now be able to use a 3 room charge item after 2 rooms instead, Does the teleport effect every time you use your current spacebar item, Can be used infinitely every room if you have Guppy's Paw and no red heart containers (Can be exploited to get to the boss room without clearing any other rooms), Higher chance for champion enemies while held, Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance, Does not attract other pickups like the full Magneto item does, Increases your chances to find an Angel Room instead of a Devil Room, Normally there is a 50%/50% chance of a Angel or Devil room with if a door spawns after the boss. Of all the tear replacer effects, I find that this isn't the strongest one overall and it's a bit tough to use, plus it overrides literally everything else. Each room is locked to a specific trinket effect, meaning if you exit and re-enter a room, that specific room will always have the same effect. Charge time increased to 4 (from 2), UNLOCK: Unlock this item by dying 100 times, * item room, treasure room, item room pool, grey, gray, Holding the active item button will deplete the charge bar. Godhead: A item that gives you amazing tears. communion, the lost item pool, circle, cross, white, yellow, +0.04 Damage Up for every coin you currently have, At 99 coins this item gives +3.96 Damage Up, +0.04 per coin is the amount added before the damage formula is calculated, as this is the only way to show a consistent amount of damage given. ?, Satan and The Lamb as Tainted Magdalene, The first time you pick this trinket up, the heart container will be filled. for example is one of the better ones and beating Greedier with Tainted Isaac wasnt too difficult. red, drip, Isaac's health is set to 1 and he also gains 9 extra lives, Each time Isaac dies, he will respawn with 1 Health, Has a chance to drop from the Super Pride mini boss, The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost), Item Pool: Devil Room, Curse Room, Red Chest, Super Pride Miniboss, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, Gives Isaac demon wings and the ability to fly, * devil pool, devil room pool, devil deal, the lost item pool, cross, upside down, red, black. Poison deals 5 damage initially and then 3.5, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac, REPENTANCE - GB Bug is now a thrown projectile, activated by double tapping an attack button. Upon hitting the last button, this unlocks a Mine Cart, which is somewhere on the floor. 1. The chance for this effect to activate depends on your Luck stat. Time is the essence", "Sleeping gatekeepers will need to be awoken with a loud sound", UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon). After reaching level 4 (and at a much lower chance before level 4), Bumbo will also continue to collect coins and drop random pickups, similar to the Bum Friend item, but can also drop pedestal items very rarely. Press question mark to learn the rest of the keyboard shortcuts. If the enemy dies while in this state they will drop 1-4 coins, Rainbow poop Dips charm enemies and have a chance to spawn 1/2 a red heart on death. the lost item pool, red, beads, grey, gray, cross, necklace, An orbital which blocks shots and damages enemies it comes into contact with for 7 damage per tick, Exclusively drops from one of the horsemen bosses, 2 cubes of meat transform the orbital into a meat head which fires blood tears which deal 3.5 damage each, 3 cubes of meat transform it into a meat boy familiar that walks around and deals 3.5 contact damage per tick to enemies, 4 cubes of meat cause the meat boy familiar to grow in size and do 5.5 damage per tick instead, Any further cubes of meat past 4 will start the cycle again, UNLOCK: Unlock this item by beating Mom for the first time, Has a very small chance to drop after destroying one of the pots that appear in the Basement and Cellar floors, Has a chance to drop from the Super Greed miniboss fight, UNLOCK: Unlock this item by beating Mom's Heart 8 times, Item Pool: Devil Room, Gold Chest, Super Greed Miniboss. 5 keys = 100% chance. Based on the Steam Workshop mod created by Jean-Alphonse, UNLOCK: Unlock this item by opening 20 locked chests, *, mr me!, Mr Meeseeks, rick and morty, brown, chest, szechuan sauce, mister me, Grants a prism orbital with a large orbital radius, Isaac's tears that pass through the prism split into four multi-colored tears, Does not deal contact damage to enemies that it passes over, Added as part of the Afterbirth+ Booster Pack #3. Taking this item DOES count as a devil deal, preventing future angel rooms. 2. Kills poop bosses when used - Dingle, Dangle and Brownie, * item room, treasure room, item room pool, silver spoon handle, grey, gray, white, toilet. The fastest, easiest way to get the five Gulp! Aries, Cancer, Capricorn, Leo etc.). Part Two Second Knife Piece. Here's the information about best items to unlock isaac People use search engines every day, but most people don't know some tricks that can help them get better search results, for example: when searching for "dog", "dog -black"(without quotation marks) can help you exclude search results that contain "black". Counts as 1 of 3 spider items needed towards the Spider Baby transformation. For the current room, tears now have the Spoon Bender effect, which allows them to curve towards enemies and gives them a purle appearance. Every few seconds all enemies gain fear effect. Deals significant contact damage to enemies while active (1600 dps). Based on the Steam Workshop mod created by Ratlah, UNLOCK: Unlock this item by sleeping in 10 different beds, When used, this item will sacrifice up to 2 of your familiars (chosen at random), and spawn a random Devil Room item for each familar sacrificed this way, In addition to the familiars, any blue flies or spiders will be converted to 1 coin each, If Guardian Angel, Sworn Protector, or Seraphim is sacrificed, Satan will be extra happy and reward you with 2 black hearts, Incubus won't be sacrificed if you're playing as Lilith, If used while you have no familiar, this item will do nothing and won't consume the item, Added as part of the Afterbirth+ Booster Pack #5. Unlock Condition: Repentance added many new items into the Secret Room that basically instantly win you the run such as the Red Key, Rock Bottom ( ), and Echo Chamber ( ). Unfortunately, some of these unlocks are obtainable while beating Mother and currently on PS4, it does happen that the game will crash while entering the fight. Press J to jump to the feed. rocks), Item Pool: Item Room, Devil Room, Greed Mode Devil Room, * item room, treasure room, item room pool, luigi board, weeja board, paper, grown, Automatically gives you 1 bar of charge after using your spacebar item, Fully recharges your current spacebar item when picked up, Any items which are normally a 1 room recharge are now timed instead, * shop room pool, shop item pool, battery, black, brown, When Isaac takes damage, the dead bird will spawn and attack nearby enemies in the current room for 2 damage per tick, * item room, treasure room, item room pool, the lost item pool, starting, grey, gray, Tears are replaced with the ability to charge and fire a powerful laser that travels in a straight line across the room, dealing a lot of damage (tear damage hits for 9 ticks per laser) to any enemies it comes into contact with, Does not directly affect your Damage stat but hits enemies 9 times per charge, Synergizes very well with a lot of items including Tammy's Head, Tiny Planet, Inner Eye (Triple Shot), Mutant Spider (Quad Shot) and many others, If you somehow manage to get a second Brimstone, the laser becomes massive and deals double damage, * devil pool, devil room pool, devil deal, infinity, red, black, Has a chance to drop while playing any Blood Donation machine, UNLOCK: Unlock this item by playing the Blood Donation machine 30 times, Item Pool: None (Blood Donation machine only), Gives you a high rate of fire in exchange for a damage down, * secret room pool, item room, treasure room, item room pool, Thin Odd Mushroom, brown, purple, grey, gray, REPENTANCE - Odd Mushroom (thick) is now a larger damage increase (equal to that of Steven/Pentagram), but now also a larger speed downgrade (from -0.1 to -0.2), * secret room pool, item room, treasure room, item room pool, purple, pink, brown, thick odd mushroom thick, When you only have half a red heart remaining or less, you enter a curse state which adds +1.5 damage and +0.3 speed, When playing as Eve, this item activates with one FULL heart remaining or less AND also removes her 0.75 damage multiplier, raising it up to 1.0, The effect is permanently active for characters with no red hearts (e.g. Kicking a frozen enemy will push it into the wall, where it shatters and fires ice shards everywhere (these can then freeze other enemies), Isaac will now automatically charge up tears, allowing you to store them up and fire them rapidly for a short time, Any time you aren't firing tears, the charge bar will start filling up, for up to 3 seconds. REPENTANCE - Mitre now only has a 33% chance to convert red heart drops into soul hearts (down from 50%). The charge direction now allows for a minor amount of control, * headless horseman, headless horsemen, red, grey, gray, A bag of bombs that will drop a bomb pickup every 2 rooms, UNLOCK: Unlock this item by beating Satan with Cain, * boss rush pool, boss rush room, secret room pool, item room, treasure room, item room pool, Cannot be obtained and has no use for any other character, Birthright is a Shop item that has unique effects depending on what character you're playing as, This is the item Tainted Blue Baby (???) These only appear if not all runes have been unlocked yet. Order of unlocks - Binding of Isaac: Rebirth Wiki Community External Communities Wiki in: Modified in Afterbirth, Modified in Afterbirth+, Modified in Repentance Order of unlocks Edit Rebirth Categories Community content is available under CC BY-NC-SA unless otherwise noted. For the biggest and best experience, you'll want the Rebirth Complete Bundle on Steam, which includes the newer base game and all three expansions, clocking in at a hefty $51 when not on sale.. Cain - +1 Luck. With +0.5 Damage being one of the possible random stat rewards, this item is really the only Damage Up you'll need for the entire run. UNLOCK: Unlock this item by beating Greed Mode with ??? Part Two Second Knife Piece. The Binding of Isaac: Repentance . ?, Satan and The Lamb as Tainted Bethany, Taking damage gives you a chance to spawn a flame orbital, similar to the ones created by Book of Virtues, Entering an Angel Room gives you +5 flame orbitals. ?, Satan and The Lamb as Tainted Judas, Changes Devil Room layouts. * arcade, skull game, black, heart, pink, love, Gives Isaac 2 orbital flies which block enemy shots, Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies, * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool, two, flies, black, When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health, Resurrection takes place before all other items which give you an extra life, * secret room pool, mario, green mushroom, extra life, spots, spotted, x1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr + Book of Belial), Increases the size of your player sprite, but doesn't increase the hitbox, Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation, Counts as 1 of 3 size-increasing items needed towards the Stompy transformation, * boss room pool, boss room item, item room, treasure room, item room pool, red, spots, spotted, amanita muscaria, Enemies touching you take 12 damage, then a poison effect is applied for 6-7 ticks, dealing damage equal to the amount of red hearts you have (up to 30.8 at 12 full red hearts), Has a chance to drop from the Lust miniboss fight, Counts as 1 of 3 syringe items needed towards the Spun transformation. For example rerolling Plan C (ID = 475) changes it into the Broken Glass Cannon, which is a hidden item with ID = 474, Items that are yet to be unlocked will also be skipped over, preventing you from getting items you don't have access to yet, UNLOCK: Unlock this item by defeating Delirium as Tainted Isaac, Upon taking damage you have a chance to drop the heart that you just lost. pedestal items, Picking up all dropped items leaves you with the same health and consumables you had before, This allows you to manipulate your consumables in lots of different ways, for example by rerolling them with the D6/D20, re-arrange your Bone heart containers and more, If you have the Tarot Cloth item, this card will also drop all your passive items on the floor as pedestals, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lost, Gives you a blue aura that repels enemy projectiles, causing them to slowly curve away from Isaac and avoid hitting him, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Judas, Causes Mom's Foot to keep stomping down randomly for 60 seconds where Isaac is standing, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lilith, Gives 2 HP Up and +1.5 Tears Up for 60 seconds, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eve, Teleports you to an extra boss room, that drops a Boss room item as normal. keys, coins, bombs, trinkets), The chance for pickups to spawn decreases by 1% each time Glitter Bombs provides something (resets at the next floor). Blood Donation machines, UNLOCK: Unlock this item by beating the Isaac boss with The Lost, * item room, treasure room, item room pool, red, isaacs heart, A familiar ghost that follows Isaac around and chases enemies close-by, damaging them for 2 contact damage and causing a fear effect, * item room, treasure room, item room pool, white, lil' haunt, A familiar beggar similar to Bum Friend that follows Isaac and collects red hearts, giving Isaac black hearts, pills, cards, runes or spiders in return, For every 1.5 red hearts he takes, he will give a reward, Reward chances: Black Heart - 40%, Card/Rune - 20%, Pill - 20%, Blue Spider - 10%, Spider 10%, Item Pool: Item Room, Devil Room, Demon Beggar, * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, celebrate good times come on, the lost item pool, qt 3.14, dark bum, otp, damn it reddit, horns, grey, gray, smile, A very large orbital that moves around Isaac very slowly, blocking shots and dealing 2 contact damage per tick, Affects the speed of all other orbitals, slowing them down a lot (NOTE: This effect does not happen until you get a new orbital after Big Fan), Does not count as one of your three standard orbital slots, * item room, treasure room, item room pool, fat, brown, An adorable friendly blue spider that walks around the room laying other blue spiders which attack enemies, She can only spawn a maximum of up to 5 spiders at a time and will only do so while there are enemies in the room, REPENTANCE - Sissy Longlegs now charms enemies upon contact, * item room, treasure room, sissy longlegs item room pool, qt 3.14, dark bum, otp, damn it reddit, blue, derpface, Spawns a friendly Mulligan that walks around the room. bad damage, bobs brain, When Isaac takes damage, a white attack fly will spawn that orbits him at a similar distance to the Distant Admiration fly, The fly orbits a lot faster than Distant Admiration or Forever Alone and deals 10 damage per tick, REPENTANCE - Best Bud's contact damage has been increased to 10 (from 5), * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. Unlock Condition: Collect 3 Astrology related items (Zodiac items, fortune-teller related items, etc.). However, If you also have flying you will always take damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, bomb, A random chance when you take damage to get an invincibility shield for 7 seconds, The chance to get an invincibility shield is affected by your luck stat and at +10 Luck it will activate every time you get hit, Converts all negative pills into their positive counterparts e.g. This deals 1 damage per tick, High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless, Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. See previous icon for normal character effects, Tainted Isaac - Adds 4 more spaces for passive items, Tainted Maggy - Adds 1 extra real heart container that doesn't deplete, Tainted Cain - Doubles picks dropped when touching an item, Tainted Judas - Increases the range in which Dark Arts hits enemies and tears, Tainted ??? While so simple in theory, Psy Fly is undoubtedly a top-tier item that players were shocked to learn is unlocked from the very start of the game. Following the path takes you to an abandoned mineshaft, which leads you to a pedestal with the Knife Piece. The game has no official release date, instead getting a release window of "Q3 2021" . Eden - Spawns 3 items from any pools, you can only take 1, The Lost - Useless items like HP upgrades, spectral tears or flight are removed from the item pools, Lilith - Causes all your offensive familiars to stack tightly infront of Lilith for more controlled damage, Apollyon - Void has a chance to spawn a previously destroyed item as well. FRA1DN0T. UNLOCK: Unlock this trinket by collecting three of the following in the same run: Magic 8 Ball, Tiny Planet, Crystal Ball, Star of Bethlehem or any of the Astrology-related items (e.g. ), REPENTANCE - The hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, red, wire, white, eye, Isaac can now charge shots for more damage by holding down the fire button, At full charge, your tears do 4 times more damage, Tears fired at the minimum possible charge do roughly 1/3 of your normal damage, You can spam the fire button to rapid fire, however the overall damage per second will be low, * item room, treasure room, item room pool, brown, glass, beaker, white, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, Which is somewhere on the floor dps ) Tainted Isaac wasnt too difficult last button, this unlocks Mine... 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